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Paul S Aisen Selected Research

alzhemed

2/2011Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study).
9/2007Alzhemed: a potential treatment for Alzheimer's disease.
7/2006Development of a disease-modifying treatment for Alzheimer's disease: Alzhemed.

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Paul S Aisen Research Topics

Disease

147Alzheimer Disease (Alzheimer's Disease)
10/2022 - 02/2002
62Cognitive Dysfunction
01/2022 - 04/2002
26Atrophy
10/2019 - 01/2010
22Dementia (Dementias)
01/2022 - 03/2009
12Disease Progression
01/2022 - 07/2008
4Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder)
06/2022 - 06/2014
4Amyloid Plaque
07/2021 - 07/2004
4Neurodegenerative Diseases (Neurodegenerative Disease)
06/2019 - 01/2009
3Traumatic Brain Injuries (Traumatic Brain Injury)
06/2022 - 06/2014
3Hypertension (High Blood Pressure)
11/2020 - 05/2003
3Down Syndrome (Down's Syndrome)
05/2016 - 10/2009
3Neurobehavioral Manifestations
04/2012 - 04/2002
2Edema (Dropsy)
07/2021 - 01/2014
2Cerebrovascular Disorders (Cerebrovascular Occlusion)
11/2020 - 01/2019
2Weight Loss (Weight Reduction)
11/2020 - 01/2018
2Diarrhea
10/2019 - 08/2011
2Tauopathies
10/2019 - 02/2013
2Wounds and Injuries (Trauma)
01/2018 - 06/2014
2Inflammation (Inflammations)
01/2017 - 12/2012
2Psychotic Disorders (Schizoaffective Disorder)
03/2014 - 08/2011
2Memory Disorders (Memory Loss)
12/2012 - 01/2011
2Stroke (Strokes)
07/2011 - 01/2005
2Poisoning
09/2008 - 12/2005
1Obesity
11/2020
1Frailty
11/2020
1Atrial Fibrillation
11/2020
1Orthostatic Hypotension (Postural Hypotension)
11/2020
1Craniocerebral Trauma (Head Injury)
11/2020
1Gastrointestinal Diseases (Functional Gastrointestinal Disorders)
10/2019
1Exanthema (Rash)
01/2018
1Chills
05/2017
1Brain Edema (Cerebral Edema)
05/2017
1Respiratory Tract Infections (Respiratory Tract Infection)
05/2017

Drug/Important Bio-Agent (IBA)

56Biomarkers (Surrogate Marker)IBA
10/2022 - 01/2009
51Amyloid (Amyloid Fibrils)IBA
10/2022 - 01/2005
28Amyloid beta-PeptidesIBA
06/2022 - 09/2002
15ApolipoproteinsIBA
06/2022 - 01/2005
15Apolipoproteins E (ApoE)IBA
01/2020 - 08/2009
9Pharmaceutical PreparationsIBA
04/2019 - 06/2003
8Peptides (Polypeptides)IBA
10/2019 - 07/2004
6Amyloid Precursor Protein Secretases (beta-Secretase)IBA
01/2021 - 01/2005
6Vitamin EFDA LinkGeneric
05/2016 - 01/2009
6Proteins (Proteins, Gene)FDA Link
07/2013 - 01/2005
5verubecestatIBA
12/2020 - 01/2018
5Donepezil (Aricept)FDA LinkGeneric
05/2017 - 01/2009
5rofecoxib (Vioxx)FDA Link
05/2017 - 04/2002
5Glucose (Dextrose)FDA LinkGeneric
04/2017 - 10/2011
4solanezumabIBA
07/2021 - 07/2012
4florbetapirIBA
01/2016 - 10/2012
4N2- ((2S)- 2- (3,5- difluorophenyl)- 2- hydroxyethanoyl)- N1- ((7S)- 5- methyl- 6- oxo- 6,7- dihydro- 5H- dibenzo(b,d)azepin- 7- yl)- L- alaninamideIBA
01/2015 - 08/2008
42- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA
01/2014 - 05/2010
3Biological ProductsIBA
07/2021 - 12/2012
3tau Proteins (tau Protein)IBA
06/2019 - 02/2009
3Receptor for Advanced Glycation End ProductsIBA
04/2014 - 07/2011
3alzhemedIBA
02/2011 - 07/2006
3VitaminsIBA
10/2008 - 03/2003
3huperzine AIBA
09/2008 - 12/2005
3Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
06/2003 - 04/2002
2Intravenous Immunoglobulins (IVIG)FDA Link
01/2018 - 05/2017
2Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2017 - 03/2012
2ResveratrolIBA
01/2017 - 10/2015
2Antipsychotic Agents (Antipsychotics)IBA
03/2014 - 03/2012
2Silver Sulfadiazine (SSD)FDA LinkGeneric
09/2013 - 04/2012
2N-Methylaspartate (NMDA)IBA
03/2012 - 01/2005
2Valproic Acid (Depakote)FDA LinkGeneric
08/2011 - 06/2009
2tramiprosateIBA
02/2011 - 09/2007
2AntioxidantsIBA
01/2009 - 02/2008
2HomocysteineIBA
10/2008 - 03/2003
2OrganophosphatesIBA
09/2008 - 12/2005
2Anti-Inflammatory Agents (Anti-Inflammatories)IBA
09/2004 - 09/2002
2Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
06/2003 - 05/2002
2Naproxen (Naprosyn)FDA LinkGeneric
06/2003 - 04/2002
2Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
06/2003 - 04/2002
1gantenerumabIBA
07/2021
1Retinaldehyde (Retinal)IBA
01/2021
1atabecestatIBA
01/2021
1lanabecestatIBA
11/2020
1Ascorbic Acid (Vitamin C)FDA LinkGeneric
11/2020
1Insulin (Novolin)FDA Link
01/2020
1Prion ProteinsIBA
10/2019
1Phosphotransferases (Kinase)IBA
10/2019
1saracatinibIBA
10/2019
1Nerve Growth Factors (Neurotrophins)IBA
01/2018
1Nerve Growth Factor (NGF)IBA
01/2018
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2018
1Rivastigmine (Exelon)FDA LinkGeneric
05/2017
1Galantamine (Galanthamine)FDA LinkGeneric
05/2017
1PrionsIBA
04/2017
1AcetylcholinesteraseIBA
01/2017
1ButyrylcholinesteraseIBA
01/2017
1Sirtuin 1IBA
01/2017
1Metalloproteases (Metalloproteinases)IBA
01/2017
1Matrix Metalloproteinases (MMPs)IBA
01/2017
1DNA (Deoxyribonucleic Acid)IBA
01/2017
1Cholinergic Antagonists (Anticholinergics)IBA
01/2016

Therapy/Procedure

19Therapeutics
01/2022 - 04/2002
10Activities of Daily Living (ADL)
01/2020 - 07/2008
5Secondary Prevention
01/2020 - 04/2010
1Investigational Therapies (Experimental Therapy)
01/2020
1Injections
01/2018